ALK7 CHO
CBP74650
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| I. Background | |
| ALK7是由ACVR1C基因编码的TGF-β超家族I型受体(又称Activin receptor type-1C),属于丝氨酸/苏氨酸激酶受体。它在脂肪组织、胰岛β细胞和下丘脑中高表达,是调控能量代谢和脂肪蓄积的关键分子。ALK7被激活后顺利获得磷酸化Smad2/3传递信号,抑制脂肪分解并促进脂质储存,其功能缺失可导致脂肪量减少并改善胰岛素敏感性,因此被视为肥胖和代谢综合征的潜在治疗靶点。此外,ALK7也参与血管平滑肌细胞凋亡和动脉粥样硬化进程。 | |
| II. Description | |
| ALK7 CHO细胞,在 CHO-K1 细胞的基础上,稳定表达 ALK7 。 | |
| III. Introduction | |
| Expressed gene: | ALK7 |
| Host Cell: | CHO-K1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+ 5 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
Figure 1. Recombinant ALK7 CHO constitutively expressing ALK7 . |
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